Acta Biologica
Vorher: Zeszyty Naukowe Uniwersytetu Szczecińskiego. Acta Biologica
Changes in innate and adaptive immune response to Lagovirus europaeus GI.1 (Rabbit Haemorrhagic Disease Virus -RHDV) infection
(Zmiany we wrodzona i nabytej odpowiedź immunologicznej po zakażeniu Lagovirus europaeus GI.1 (Rabbit Haemorrhagic Disease Virus – RHDV))
DOI: 10.18276/ab.2020.27-08
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| ISSN: | 2450-8330 |
| eISSN: | 2353-3013 |
| Autoren: |
Beata
Hukowska-Szematowicz
Institute of Biology, University of Szczecin, Wąska 13, 71-412 Szczecin, Poland Molecular Biology and Biotechnology Center, University of Szczecin, Wąska 13, 71-412 Szczecin, Poland |
| Schlüsselbegriffe: | neutrofil limfocyty infekcja wirusowa królik wirus krwotocznej choroby królików |
| Erscheinungsdatum der Ausgabe / Monografie: | 2020 |
| Seitenanzahl: | 15 (77-91) |
| OAI-PMH: | Metadaten |
Abstract
Lagovirus europaeus GI.1 (Rabbit Haemorrhagic Disease Virus – RHDV) infekuje króliki do-
mowe i dzikie na całym świecie, wywołując u nich krwotoczną chorobę królików (RHD-rabbit haemorrhagic disese). Z uwagi na fakt, że wpływ RHDV na organizm żywiciela, a dokładniej jego wpływ na układ odpornościowy, ma kluczowe znaczenie dla rozprzestrzeniania się tej infekcji u królików, bardzo ważne jest poznanie roli elementów układu odpornościowego w przebiegu zakażenia tym wirusem. Dlatego też celem badań było przedstawienie zmian we wrodzonej i nabytej odpowiedzi immunologicznej po zakażeniu trzema szczepami (V411, 1092V, Wika) Lagovirus europaeus GI.1 (RHDV), zidentyfikowanymi w różnym czasie. W za-kresie wrodzonej odpowiedzi immunologicznej zbadano dwanaście wskaźników, a w nabytej dziewięć. Uzyskane rezultaty wskazują na udział komórek PMN (polimorfonuklearnych, neu-trofilii) jako ważnych elementów w odpowiedzi na to zakażenie oraz rzucają nowe spojrzenie na udział limfocytów CD4+ Th i CD8+ Tc. Najbardziej immunogenny okazał się szczepem Wika z 1996 r.
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