ISSN: 2300-9705
eISSN: 2353-2807
OAI
DOI: 10.18276/cej.2021.4-06
Lista wydań /
Vol. 36, No. 4/2021
Genetic Variation as a Possible Explanation for the Heterogeneity of Pain in Tendinopathy: What can we learn from other pain syndromes?
| Autorzy: |
Nonhlanhla S.
Mkumbuzi
Division of Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town. P.O. Box 115, Newlands, Cape Town, 7725, South Africa Michael Posthumus
Division of Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town. P.O. Box 115, Newlands, Cape Town, 7725, South Africa Alison V. September
Division of Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town. P.O. Box 115, Newlands, Cape Town, 7725, South Africa Malcolm Collins
Division of Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town. P.O. Box 115, Newlands, Cape Town, 7725, South Africa |
| Słowa kluczowe: | tendon pain genetics extracellular matrix genes inflammation genes COMT |
| Data publikacji całości: | 2021 |
| Liczba stron: | 16 (57-72) |
Abstrakt
The mechanisms of pain in tendinopathy are unclear. Current theories implicate tendon structural changes, neovascularisation, inflammation or changes in central pain processing. As with other types of musculoskeletal pain, tendon pain has high interindividual variability and, as with other types of pain, this could be attributed to genetic variation. Notably, the association between certain genetic polymorphisms and susceptibility to tendinopathy is well established in the literature. Therefore, the investigation of the mechanisms of tendon pain should also extend to include genetic variation as a possible explanation for the clinical features of tendon pain. This review summarises the current knowledge on genetic contributors to chronic pain and highlights findings that are relevant to chronic tendon pain. In particular, based on the current hypotheses on the possible sources of tendon pain, it focuses on findings that relate to genes that encode structural connective tissue components, inflammatory markers, ion channels and catecholamines and how they may relate to chronic tendon pain. In the absence of a definitive mechanism of tendon pain, an a priori genetic approach that is guided by these current hypotheses may help elucidate the mechanisms of tendon pain which may allow a more rational approach to research and treatment.
Pobierz plik
Plik artykułu
Bibliografia
| 1. | Abate, M., Silbernagel, K.G., Siljeholm, C., Di Iorio, A., De Amicis, D., Salini, V., Werner, S., Paganelli, R. (2009). Pathogenesis of tendinopathies: inflammation or degeneration? Arthritis Research & Therapy, 11 (3), 235. DOI: 10.1186/ar2723. |
| 2. | Abrahams, Y., Laguette, M.J., Prince, S., Collins, M. (2013). Polymorphisms within the COL5A1 3???-UTR That Alters mRNA Structure and the MIR608 Gene are Associated with Achilles Tendinopathy. Annals of Human Genetics, 77 (3), 204–214. DOI: 10.1111/ahg.12013. |
| 3. | Alakhdar Mohmara, Y., Cook, J., Bemtez-Martmez, J.C., McPeek, E.R., Aguilar, A.A., Olivas, E.S., Hernandez-Sanchez, S. (2020). Influence of genetic factors in elbow tendon pathology: a case-control study. Scientific Reports, 10 (1), 1–8. DOI: 10.1038/ s41598-020-63030-7. |
| 4. | Applebaum, E., Nackley, A.G., Bair, E., Maixner, W., Khan, A.A. (2015). Genetic Variants in Cyclooxygenase-2 Contribute to Post-treatment Pain among Endodontic Patients. Journal of Endodontics, 41 (8), 1214–1218. DOI: 10.1016/j.joen.2015.04.021. |
| 5. | Avcin, T., Makitie, O., Susic, M., Miller, S., Thorne, C., Tenenbaum, J., Laxer, R.M., Cole, WG. (2008). Early-onset osteoarthritis due to otospondylomegaepiphyseal dysplasia in a family with a novel splicing mutation of the COL11A2 gene. Journal of Rheumatology, 35 (5), 920–926. |
| 6. | Azimzadeh, P., Khorram Khorshid, H.R., Akhondi, M.M., Shirazi, A. (2016). Association of interleukin-16 polymorphisms with disease progression and susceptibility in endometriosis. International Journal of Immunogenetics, 43 (5), 297–302. DOI: 10.1111/iji.12281. |
| 7. | Bakkegaard, M., Johannsen, F.E., Højgaard, B., Langberg, H. (2015). Ultrasonography as a prognostic and objective parameter in Achilles tendinopathy: A prospective observational study. European Journal of Radiology, 84 (3), 458–462. DOI: 10.1016/j.ejrad.2014.11.028. |
| 8. | Bali, K.K., Hackenberg, M., Lubin, A., Kuner, R., Devor, M. (2014). Sources of individual variability: MiRNAs that predispose to neuropathic pain identified using genome-wide sequencing. Molecular Pain, 10 (1), 1–15. DOI: 10.1186/1744-8069-10-22. |
| 9. | Barbosa, F.R., Matsuda, J.B., Mazucato, M., De Castro Franęa, S., Zingaretti, S.M., Da Silva, L.M., Martinez-Rossi, N.M., Junior, M.F., Marins, M., Fachin, A.L. (2012). Influence of catechol-O-methyltransferase (COMT) gene polymorphisms in pain sensibility of Brazilian fibromialgia patients. Rheumatology International, 32 (2), 427–430. DOI: 10.1007/s00296-010-1659-z. |
| 10. | Battery, L., Maffulli, N. (2011). Inflammation in overuse tendon injuries.Sports Medicine and Arthroscopy Review, 19 (3), 213–217. DOI:10.1097/JSA.0b013e31820e6a92. |
| 11. | Baumbauer, K.M., Ramesh, D., Perry, M., Carney, K.B., Julian, T., Glidden, N., Dorsey, S.G., Starkweather, A.R., Young, E.E. (2020). Contribution of COMT and BDNF Genotype and Expression to the Risk of Transition from Acute to Chronic Low Back Pain. Clinical Journal of Pain, 36 (6), 430–439. DOI: 10.1097/AJP.0000000000000819. |
| 12. | Berta, T., Lee, J.E., Park, C.-K. (2017). Unconventional role of caspase-6 in spinal microglia activation and chronic pain: Invited review for Mediators of Inflammation. Microglia in Health and Disease: A Double-Edge Sword, Special Issue, 2017, 1–8. DOI: 10.1155/2017/9383184. |
| 13. | Bessler, H., Shavit, Y., Mayburd, E., Smirnov, G., Beilin, B. (2006). Postoperative pain, morphine consumption, and genetic polymorphism of IL-ip and IL-1 receptor antagonist. Neuroscience Letters, 404 (1–2), 154–158. DOI: 10.1016/j.neulet.2006.05.030. |
| 14. | Białecka, M., Jurewicz, A., Machoy-Mokrzyńska, A., Kurzawski, M., Leźnicka, K., Dziedziejko, V., Safranow, K., Droździk, M., Bohatyrewicz, A. (2016). Effect of interleukin 6-174G>C gene polymorphism on opioid requirements after total hip replacement. Journal of Anesthesia, 30 (4), 562–567. DOI: 10.1007/s00540-016-2167-4. |
| 15. | Bjersing, J.L., Bokarewa, M.I., Mannerkorpi, K. (2015). Profile of circulating microRNAs in fibromyalgia and their relation to symptom severity: an exploratory study. Rheumatology International, 35 (4), 635–642. DOI: 10.1007/s00296-014-3139-3. |
| 16. | Bjorland, S., Moen, A., Schistad, E., Gjerstad, J., Røe, C. (2016). Genes associated with persistent lumbar radicular pain; a systematic review. BMC Musculoskeletal Disorders, 17 (1), 1–10. DOI: 10.1186/s12891-016-1356-5. |
| 17. | Blesneac, I., Themistocleous, A.C., Fratter, C., Conrad, L.J., Ramirez, J D., Cox, J.J., Tesfaye, S., Shillo, P.R., Rice, A.S.C., Tucker, S.J., Bennett, D.L.H. (2018). Rare NaV1.7 variants associated with painful diabetic peripheral neuropathy. Pain, 159 (3), 469–480. DOI: 10.1097/j.pain.0000000000001116. |
| 18. | Boadas-Vaello, P., Homs, J., Reina, F., Carrera, A., Verdu, E. (2017). Neuroplasticity of Supraspinal Structures Associated with Pathological Pain. Anatomical Record, 300 (8), 1481–1501. DOI: 10.1002/ar.23587. |
| 19. | Bortsov, A.V., Devor, M., Kaunisto, M.A., Kalso, E., Brufsky, A., Kehlet, H., Aasvang, E., Bittner, R., Diatchenko, L., Belfer, I. (2019). CACNG2 polymorphisms associate with chronic pain after mastectomy. Pain, 160 (3), 561–568. DOI: 10.1097/j.pain.0000000000001432. |
| 20. | Brenton, A., Lee, C., Kabaria, S., Hafez, M., Kantorovich, S., Meshkin, B. (2017). (402) Association of Catechol-O-Methyltransferase Single Nucleotide Polymorphisms, Ethnicity, and Sex in a Large Cohort of Fibromyalgia Patients. The Journal of Pain, 18 (4), S75. DOI: 10.1016/j.jpain.2017.02.252. |
| 21. | Burger, M.C., de Wet, H., Collins, M. (2015). Interleukin and growth factor gene variants and risk of carpal tunnel syndrome. Gene, 564 (1), 67–72. DOI: 10.1016/j.gene.2015.03.047. |
| 22. | Caneiro, J.P., Roos, E.M., Barton, C.J., O’Sullivan, K., Kent, P., Lin, I., Choong, P., Crossley, KM., Hartvigsen, J., Smith, A.J., O’Sullivan, P. (2020). It is time to move beyond a € body region silos’ to manage musculoskeletal pain: Five actions to change clinical practice. British Journal of Sports Medicine, 54 (8), 438–439. DOI: 10.1136/bjsports-2018-100488. |
| 23. | Chidambaran, V., Gang, Y., Pilipenko, V., Ashton, M., Ding, L. (2019). Systematic Review and Meta-Analysis of Genetic Risk of Developing Chronic Postsurgical Pain. Journal of Pain, 00 (00). DOI: 10.1016/j.jpain.2019.05.008. |
| 24. | Ciszek, B.P., Khan, A.A., Dang, H., Slade, G.D., Smith, S., Bair, E., Maixner, W., Zolnoun, D., Nackley, A.G. (2015). MicroRNA expression profiles differentiate chronic pain condition subtypes. Translational Research, 166 (6), 706–720.e11. DOI: 10.1016/j.trsl.2015.06.008. |
| 25. | Cook, J.L., Purdam, C.R. (2009). Is tendon pathology a continuum? A pathology model to explain the clinical presentation of load-induced tendinopathy. British Journal of Sports Medicine, 43 (6), 409-416. DOI: 10.1136/bjsm.2008.051193. |
| 26. | Costigan, M., Belfer, I., Griffin, R.S., Dai, F., Barrett, L.B., Coppola, G., Wu, T., Kiselycznyk, C., Poddar, M., Lu, Y., Diatchenko, L., Smith, S., Cobos, E.J., Zaykin, D., Allchorne, A., Shen, P.H., Nikolajsen, L., Karppinen, J., Männikkö, M., Kelempisioti, A., Goldman, D., Maixner, W., Geschwind, D.H., Max, M.B., Seltzer, Z., Woolf, C.J. (2010). Multiple chronic pain states are associated with a common amino acid-changing allele in KCNS1. Brain, 133 (9), 2519–2527. DOI: 10.1093/brain/awq195. |
| 27. | D’Addona, A., Maffulli, N., Formisano, S., Rosa, D. (2017). Inflammation in tendinopathy. Surgeon, 15 (5), 297–302. DOI: 10.1016/j.surge.2017.04.004. |
| 28. | Dada, S., Burger, M.C., Massij, F., de Wet, H., Collins, M. (2016). Carpal tunnel syndrome:The role of collagen gene variants. Gene, 587 (1), 53–58. DOI: 10.1016/j.gene.2016.04.030. |
| 29. | Dakin, S.G., Dudhia, J., Smith, R.K.W. (2014). Resolving an inflammatory concept: The importance of inflammation and resolution in tendinopathy. Veterinary Immunology and Immunopathology, 158 (3–4), 21–127. DOI: 10.1016/j.vetimm.2014.01.007. |
| 30. | Dayer, C.F., Luthi, F., Le Carre, J., Vuistiner, P., Terrier, P., Benaim, C., Giacobino, J.P., Leger, B. (2019). Differences in the miRNA signatures of chronic musculoskeletal pain patients from neuropathic or nociceptive origins. PLoS ONE, 14 (7), 1–21. DOI:10.1371/journal.pone.0219311. |
| 31. | Dean, B.J.F., Snelling, S.J.B., Dakin, S.G., Murphy, R.J., Javaid, M.K., Carr, A. J. (2015). Differences in glutamate receptors and inflammatory cell numbers are associated with the resolution of pain in human rotator cuff tendinopathy. Arthritis Research and Therapy, 17 (1), 1–10. DOI: 10.1186/s13075-015-0691-5. |
| 32. | Diatchenko, L., Slade, G.D., Nackley, A.G., Bhalang, K., Sigurdsson, A., Belfer, I., Goldman, D., Xu, K., Shabalina, S.A., Shagin, D., Max, M.B., Makarov, S.S., Maixner, W. (2005). Genetic basis for individual variations in pain perception and the development of a chronic pain condition. Human Molecular Genetics, 14 (1), 135–143. DOI: 10.1093/hmg/ddi013. |
| 33. | Diniz-Fernandes, T., Godoy-Santos, A.L., Santos, M.C., Pontin, P., Pereira, C.A.A., Jardim, Y.J., Velosa, A.P.P., Maffulli, N., Teodoro, W.R., Capelozzi, V.L. (2018). Matrix metalloproteinase-1 (MMP-1) and (MMP-8) gene polymorphisms promote increase and remodeling of the collagen iii and v in posterior tibial tendinopathy.Histology and Histopathology, 33 (9), 929–936. DOI: 10.14670/HH-11-982. |
| 34. | Docking, S.I., Ooi, C.C., Connell, D. (2015). Tendinopathy: Is imaging telling us the entire story? Journal of Orthopaedic and Sports Physical Therapy, 45 (11), 842–852. DOI: 10.2519/jospt.2015.5880. |
| 35. | Duan, G., Xiang, G., Guo, S., Zhang, Y., Ying, Y., Huang, P., Zheng, H., Zhang, M., Li, N., Zhang, X. (2016). Genotypic Analysisof SCN9A for Prediction of Postoperative Pain in Female Patients Undergoing Gynecological Laparoscopic Surgery. Pain Physician, 19, E151–162. |
| 36. | Dussor, G. (2015). ASICs as therapeutic targets for migraine.Neuropharmacology, 94, 64–71. DOI: 10.1016/j.neuropharm.2014.12.015. |
| 37. | Egan, M.F., Goldberg, T.E., Kolachana, B.S., Callicott, J.H., Mazzanti, C.M., Straub, R.E., Goldman, D., Weinberger, D.R. (2001). Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proceedings of the National Academy of Sciences of the United States of America, 98 (12), 6917–6922. DOI: 10.1073/pnas.111134598. |
| 38. | El Khoury, L., Ribbans, W.J., Raleigh, S M. (2016). MMP3 and TIMP2 gene variants as predisposing factors for Achilles tendon pathologies: Attempted replication study in a British case-control cohort. Meta Gene, 9, 52–55. DOI: 10.1016/j.mgene.2016.03.007. |
| 39. | Elramah, S., Landry, M., Favereaux, A. (2014). MicroRNAs regulate neuronal plasticity and are involved in pain mechanisms. Frontiers in Cellular Neuroscience, 8 (FEB), 1–15. DOI: 10.3389/fncel.2014.00031. |
| 40. | Estacion, M., Harty, T.P., Choi, J.S., Tyrrell, L., Dib-Hajj, S.D., Waxman, S.G. (2009). Asodium channel gene SCN9A polymorphism that increases nociceptor excitability. Annals of Neurology, 66 (6), 862–866. DOI: 10.1002/ana.21895. |
| 41. | Femandez-De-Las-Penas, C., Ambite-Quesada, S., Palacios-Cena, M., Guillem-Mesado, A., Guerrero-Peral, A., Pareja, J.A., Arendt-Nielsen, L. (2019). Catechol-O-Methyltransferase (COMT) rs4680 Val158Met Polymorphism is Associated With Widespread Pressure Pain Sensitivity and Depression in Women With Chronic, but not Episodic, Tension-Type Headache. Clinical Journal of Pain, 35 (4), 345–352. DOI: 10.1097/AJP.0000000000000684. |
| 42. | Fillingim, R.B., Wallace, M.R., Herbstman, D.M., Ribeiro-Dasilva, M., Staud, R. (2008). Genetic contributions to pain: Areview of findings in humans, Oral Diseases, 14 (8), 673–682.DOI: 10.1111/j.1601-0825.2008.01458.x. |
| 43. | Foulkes, T., Wood, J.N. (2008). Pain genes. PLoS Genetics, 4 (7), 1–9. DOI: 10.1371/journal.pgen.1000086. |
| 44. | Gammaitoni, A.R., Goitz, H.T., Marsh, S., Marriott, T B., Galer, B.S. (2013). Heated lidocaine/tetracaine patch for treatment of patellar tendinopathy pain. Journal of Pain Research, 6, 565–570. DOI: 10.2147/JPR.S46239. |
| 45. | Gan, X.-L., Lin, Y.-H., Zhang, Y., Yu, T.-H., Hu, L.-N. (2010). Associationof an Interleukin-16 Gene Polymorphism with the Risk and Pain Phenotype of Endometriosis. DNA and Cell Biology, 29 (11), 663–667. DOI: 10.1089/dna.2010.1049. |
| 46. | Govil, M., Mukhopadhyay, N., Holwerda, T., Sluka, K., Rakel, B., Schutte, D.L. (2020). Effects of genotype on TENS effectiveness in controlling knee pain in persons with mild to moderate osteoarthritis. European Journal of Pain (United Kingdom), 24 (2), 398–412. DOI: 10.1002/ejp.1497. |
| 47. | Guo, T.M., Liu, M., Zhang, Y.G., Guo, W.T., Wu, S.X. (2011). Association between caspase-9 promoter region polymorphisms and discogenic low back pain. Connective Tissue Research, 52 (2), 133–138. DOI: 10.3109/03008207.2010.487621. |
| 48. | Hagen, K., Pettersen, E., Stovner, L.J., Skorpen, F., Zwart, J. (2006). Val158Met polymorphism in the Catechol-O-methyltransferase. BMC Musculoskeletal Disorders, 5, 4–8. DOI: 10.1186/1471-2474-7-40. |
| 49. | Hay, M., Patricios, J., Collins, R., Branfield, A., Cook, J., Handley, C.J., September, A.V., Posthumus, M., Collins, M. (2013). Association of type XI collagen genes with chronic Achilles tendinopathy in independent populations from South Africa and Australia. British Journal of Sports Medicine, 47 (9), 569–574. DOI: 10.1136/bjsports-2013-092379. |
| 50. | Ho, K.W.D., Wallace, M.R., Sibille, K.T., Bartley, E.J., Cruz-Almeida, Y., Glover, T.L., King, C.D., Goodin, B.R., Addison, A., Edberg, J.C., Staud, R., Bradley, L.A., Fillingim, R.B. (2017). Single Nucleotide Polymorphism in the COL11A2 Gene Associated with Heat Pain Sensitivity in Knee Osteoarthritis. Molecular Pain, 13, 1–11. DOI: 10.1177/1744806917724259. |
| 51. | Hoeijmakers, J., Merkies, I., Gerrits, M., Waxman, S., Faber, C. (2012). Genetic aspects of sodium channelopathy in small fiber neuropathy. Clinical Genetics, 82 (4), 351–358. DOI: 10.1111/j.1399-0004.2012.01937.x. |
| 52. | Holliday, K.L., Thomson, W., Neogi, T., Felson, D.T., Wang, K., Wu, F.C., Huhtaniemi, I.T., Bartfai, G., Casanueva, F., Forti, G., Kula, K., Punab, M., Vanderschueren, D., Macfarlane, G.J., Horan, M.A., Ollier, W., Payton, A., Pendleton, N., McBeth, J. (2012).The non-synonymous SNP, R1150W, in SCN9A is not associated with chronic widespread pain susceptibility. Molecular Pain, 8 (1), 1.DOI: 10.1186/1744-8069-8-72. |
| 53. | Hooten, W.M., Hu, D., Cunningham, J.M., Iii, J.L.B. (2019). Effect of catechol-O-methyltransferase on opioid-induced hyperalgesia in adults with chronic pain. DOI: 10.1177/1744806919848929. |
| 54. | Huang, J., Yang, Y., Zhao, P., Gerrits, M.M., Hoeijmakers, J.G.J., Bekelaar, K., Merkies, I.S.J., Faber, C.G., Dib-Hajj, S.D., Waxman, S.G. (2013). Small-Fiber Neuropathy Nav1.8 Mutation Shifts Activation to Hyperpolarized Potentials and Increases Excitability of Dorsal Root Ganglion Neurons. Journal of Neuroscience, 33 (35), 14087–14097. DOI: 10.1523/JNEUROSCI.2710-13.2013. |
| 55. | Jacobsen, L.M., Schistad, E.I., Storesund, A., Pedersen, L.M., Espeland, A., Rygh, L.J., R0e, C., Gjerstad, J. (2013). The MMP1 rs1799750 2G allele is associated with increased low back pain, sciatica, and disability after lumbar disk herniation. Clinical Journal of Pain, 29 (11), 967–971. DOI: 10.1097/AJP.0b013e31827df7fd. |
| 56. | Ji, R.R., Gereau IV, R.W., Malcangio, M., Strichartz, G.R. (2009). MAP kinase and pain.Brain Research Reviews, 60 (1), 135–148. DOI: 10.1016/j.brainresrev.2008.12.011. |
| 57. | Joseph, E.K., Levine, J.D. (2004). Caspase signalling in neuropathic and inflammatory pain in the rat. European Journal of Neuroscience, 20 (11), 2896–2902. DOI: 10.1111/j.1460-9568.2004.03750.x. |
| 58. | Kambur, O., Kaunisto, M.A., Tikkanen, E., Leal, S.M., Ripatti, S., Kalso, E.A. (2013). Effect of catechol-o-methyltransferase-gene(COMT) variants on experimental and acute postoperative pain in 1,000 women undergoing surgery for breast cancer. Anesthesiology, 119 (6), 1422–1433. DOI: 10.1097/aln.0000000000000013. |
| 59. | Kang, X., Tian, B., Zhang, L., Ge, Z., Zhao, Y., Zhang, Y. (2019). Relationship of common variants in MPP7, TIMP2 and CASP8 genes with the risk of chronic achilles tendinopathy. Scientific Reports, 9 (1), 1–6. DOI: 10.1038/s41598-019-54097-y. |
| 60. | Khoury, L. El, Posthumus, M., Collins, M., Van Der Merwe, W., Handley, C., Cook, J., Raleigh, S.M. (2015). ELN and FBN2 gene variants as risk factors for two sports-related musculoskeletal injuries. International Journal of Sports Medicine, 36 (4), 333–337. DOI:10.1055/s-0034-1390492. |
| 61. | Knisely, M.R., Conley, Y.P., Kober, K.M., Smoot, B., Paul, S.M., Levine, J.D., Miaskowski, C. (2018). Associations Between Catecholaminergic and Serotonergic Genes and Persistent Breast Pain Phenotypes After Breast Cancer Surgery. Journal of Pain, 19 (10), 1130–1146. DOI: 10.1016/j.jpain.2018.04.007. |
| 62. | Kolesnikov, Y., Gabovits, B., Levin, A., Veske, A., Qin, L., Dai, F., Belfer, I. (2013). Chronic pain after lower abdominal surgery: Do catechol-O-methyl transferase/opioid receptor p-1 polymorphisms contribute? Molecular Pain, 9 (1), 1. DOI: 10.1186/1744-8069-9-19. |
| 63. | Kozlovskaia, M., Vlahovich, N., Ashton, K.J., Hughes, D.C. (2017). Biomedical Risk Factorsof Achilles Tendinopathy in Physically Active People: a Systematic Review. Sports Medicine – Open, 3 (1), 1–14. DOI: 10.1186/s40798-017-0087-y. |
| 64. | Kular, L., Rivat, C., Lelongt, B., Calmel, C., Laurent, M., Pohl, M., Kitabgi, P., Melik-Parsadaniantz, S., Martinerie, C. (2012). NOV/CCN3 attenuates inflammatory pain through regulation of matrix metalloproteinases-2 and -9. Journal of Neuroinflammation, 9, 1–20. DOI: 10.1186/1742-2094-9-36. |
| 65. | Lagas, I.F., Fokkema, T., Verhaar, J.A.N., Bierma-Zeinstra, S.M.A., van Middelkoop, M., de Vos, R.J. (2020). Incidence of Achilles tendinopathy and associated risk factors in recreational runners: A large prospective cohort study. Journal of Science and Medicine in Sport, 23 (5), 448–452. DOI: 10.1016/j.jsams.2019.12.013. |
| 66. | Lapvetelainen, T., Hyttinen, M.M., Saamanen, A.M., Langsjo, T., Sahlman, J., Felszeghy, S., Vuorio, E., Helminen, H.J. (2002).Lifelong voluntary joint loading increases osteoarthritis in mice housing a deletion mutation in type II procollagen gene, and also in non- transgenic mice. Annals of the Rheumatic Diseases, 61 (9), 810–817. DOI: 10.1136/ard.61.9.810. |
| 67. | Lee, P.J., Delaney, P., Keogh, J., Sleeman, D., Shorten, G.D. (2011). Catecholamine-O-Methyltransferase Polymorphisms. 27 (2), 93–101. |
| 68. | Leinders, M., Uęeyler, N., Thomann, A., Sommer, C. (2017). Aberrant microRNA expression in patients with painful peripheral neuropathies. Journal of the Neurological Sciences, 380, 242–249. DOI: 10.1016/j.jns.2017.07.041. |
| 69. | Li, J., Xu, L., Deng, X., Jiang, C., Pan, C., Chen, L., Han, Y., Dai, W., Hu, L., Zhang, G., Cheng, Z., Liu, W. (2016). N-acetyl-cysteine attenuates neuropathic pain by suppressing matrix metalloproteinases. Pain, 157 (8), 1711–1723. DOI: 10.1097/j.pain.0000000000000575. |
| 70. | Li, W., Chen, Y., Yin, B., Zhang, L. (2014). Pain in parkinson’s disease associated with COMT gene polymorphisms. Behavioural Neurology. DOI: 10.1155/2014/304203. |
| 71. | Lian, Ø., Dahl, J., Ackermann, P.W., Frihagen, F., Engebretsen, L., Bahr, R. (2006). Pronociceptive and antinociceptive neuromediators in patellar tendinopathy. American Journal of Sports Medicine, 34 (11), 1801–1808. DOI: 10.1177/0363546506289169. |
| 72. | Lin, C.-H., Chaudhuri, K.R., Fan, J.-Y., Ko, C.-I., Rizos, A., Chang, C.-W., Lin, H.-I., Wu, Y.-R. (2017). Depression and Catechol-O-methyltransferase (COMT) genetic variants are associated with pain in Parkinson’s disease.Scientific Reports, 7 (1), 6306. DOI: 10.1038/s41598-017-06782-z. |
| 73. | Linnstaedt, S.D., Walker, M.G., Parker, J.S., Yeh, E., Sons, R.L., Zimny, E., Lewandowski, C., Hendry, P.L., Damiron, K., Pearson, C., Velilla, M.A., O’Neil, B. J., Jones, J., Swor, R., Domeier, R., Hammond, S., McLean, S.A. (2015). MicroRNA circulating in the early aftermath of motor vehicle collision predict persistent pain development and suggest a role for microRNA in sex-specific pain differences. Molecular Pain, 11 (1), 1–11. DOI: 10.1186/s12990-015-0069-3. |
| 74. | Martmez-Jauand, M., Sitges, C., Rodriguez, V., Picornell, A., Ramon, M., Buskila, D., Montoya, P. (2013). Pain sensitivity in fibromyalgia is associated with catechol-O- methyltransferase (COMT) gene.European Journal of Pain (United Kingdom), 17 (1), 16–27. DOI: 10.1002/j.1532-2149.2012.00153.x. |
| 75. | Martire, L.M., Wilson, S.J., Small, B.J., Conley, Y.P., Janicki, P.K., Sliwinski, M.J. (2016). COMT and OPRM1 genotype associations with daily knee pain variability and activity induced pain. Scandinavian Journal of Pain, 10, 6–12. DOI: 10.1016/j.sjpain.2015.07.004. |
| 76. | Mc Auliffe, S., Synott, A., Casey, H., Mc Creesh, K., Purtill, H., O’Sullivan, K. (2017). Beyond the tendon: Experiences and perceptions of people with persistent Achilles tendinopathy. Musculoskeletal Science and Practice , 29, 108–114. DOI: 10.1016/j.msksp.2017.03.009. |
| 77. | McCann, B., Miaskowski, C., Koetters, T., Baggott, C., West, C., Levine, J.D., Elboim, C., Abrams, G., Hamolsky, D., Dunn, L., Rugo, H., Dodd, M., Paul, S.M., Cooper, J., Cooper, B., Schmidt, B., Langford, D., Cataldo, J., Aouizerat, B.E. (2012). Associations between pro- and anti-inflammatory cytokine genes and breast pain in women prior to breast cancer surgery.Journal of Pain, 13 (5), 425–437. DOI: 10.1016/j.jpain.2011.02.358. |
| 78. | Millan, M.J. (1999). The induction of pain: An integrative review. Progress in Neurobiology, 57 (1), 1–164. DOI: 10.1016/S0301-0082(98)00048-3. |
| 79. | Miranpuri, G.S., Schomberg, D.T., Alrfaei, B., King, K.C., Rynearson, B., Wesley, V.S., Khan, N., Obiakor, K., Wesley, U.V., Resnick, D.K. (2016). Role of matrix metalloproteinases 2 in spinal cord injury-induced neuropathic pain. Annals of Neurosciences, 23 (1), 25–32. DOI: 10.1159/000443553. |
| 80. | Mkumbuzi, N.S., September, A.V., Posthumus, M., Oulo, B., Mafu, T.S., Collins, M. (2020). Characterisation of Achilles tendon pain in recreational runners using multidimensional pain scales. Journal of Science and Medicine in Sport, 23 (3), 258–263. DOI: 10.1016/j.jsams.2019.10.016. |
| 81. | Mladenovic, I., Krunic, J., Supic, G., Kozomara, R., Bokonjic, D., Stojanovic, N., Magic, Z. (2018). Pulp Sensitivity: Influence of Sex, Psychosocial Variables, COMT Gene, and Chronic Facial Pain. Journal of Endodontics, 44 (5), 717–721.e1. DOI: 10.1016/j.joen.2018.02.002. |
| 82. | Moen, A., Schistad, E.I., Rygh, L.J., Re, C., Gjerstad, J. (2014). Roleof IL1A rs1800587, IL1B rs1143627 and IL1RN rs2234677 genotype regarding development of chronic lumbar radicular pain; A prospective one-year study. PLoS ONE, 9 (9), 1–5. DOI: 10.1371/journal.pone.0107301. |
| 83. | Mousavizadeh, R., Khosravi, S., Behzad, H., McCormack, R.G., Duronio, V., Scott, A. (2014). Cyclic strain alters the expression and release of angiogenic factors by human tendon cells. PLoS ONE, 9 (5). DOI: 10.1371/journal.pone.0097356. |
| 84. | Mu, J., Ge, W., Zuo, X., Chen, Y., Huang, C. (2013). Analysis of association between IL-1^, CASP-9, and GDF5 variants and low-back pain in Chinese male soldiers. J Neurosurg Spine, 19, 243–247. |
| 85. | Nascimento, T.D., Yang, N., Salman, D., Jassar, H., Kaciroti, N., Bellile, E., Danciu, T., Koeppe, R., Stohler, C., Zubieta, J.K., Ellingrod, V., DaSilva, A.F. (2019). p-Opioid Activity in Chronić TMD Pain Is Associated with COMT Polymorphism. Journal of Dental Research, 98 (12), 1324–1331. DOI: 10.1177/0022034519871938. |
| 86. | Neely, G.G., Hess, A., Costigan, M., Keene, A.C., Goulas, S., Langeslag, M., Griffin, R.S., Belfer, I., Dai, F., Smith, S.B., Diatchenko, L., Gupta, V., Xia, C-P., Amann, S., Kreitz, S., Heindl-Erdmann, C., Wolz, S., Ly, C.V., Arora, S., Sarangi, R., Dan, D., Novatchkova, M Rosenzweig, M., Gibson, D.G., Truong, D., Schramek, D., Zoranovic, T., Cronin, S.J.F., Angjeli, B., Brune, K., Dietzl, G., Maixner, W., Meixner, A., Thomas, W., Pospisilik, J.A., Alenius, M., Kress, M., Subramaniam, S., Garrity, P.A., Bellen, H.J., Woolf, C.J., Penninger, J.M. (2010). A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene. NIH Public Access, 143 (4), 628–638. DOI: 10.1016/j.cell.2010.09.047. |
| 87. | Nell, E.M., Van Der Merwe, L., Cook, J., Handley, C.J., Collins, M., September, A.V. (2012). The apoptosis pathway and the genetic predisposition to Achilles tendinopathy. Journal of Orthopaedic Research, 30 (11), 1719–1724. DOI: 10.1002/jor.22144. |
| 88. | Nicholl, B.I., Holliday, K.L., Macfarlane, G.J., Thomson, W., Davies, K.A., O’Neill, T.W., Bartfai, G., Boonen, S., Casanueva, F., Finn, J.D., Forti, G., Giwercman, A., Huhtaniemi, I.T., Kula, K., Punab, M., Silman, A.J., Vanderschueren, D., Wu, F.C. W., McBeth, J., Jiang, M. (2010). No evidence for a role of the catechol-O-methyltransferase pain sensitivity haplotypes in chronic widespread pain. Annals of the Rheumatic Diseases, 69 (11), 2009–2012. DOI: 10.1136/ard.2009.126086. |
| 89. | Olesen, A.E., Nielsen, L M., Feddersen, S., Erlenwein, J., Petzke, F., Przemeck, M., Christrup, L.L., Drewes, A.M. (2018). Association Between Genetic Polymorphisms and Pain Sensitivity in Patients with Hip Osteoarthritis. Pain Practice, 18 (5), 587–596. DOI: 10.1111/papr.12648. |
| 90. | Omair, A., Mannion, A.F., Holden, M., Fairbank, J., Lie, B.A., Hagg, O., Fritzell, P., Brox, J.I. (2015). Catechol-O-methyltransferase (COMT) gene polymorphisms are associated with baseline disability but not long-term treatment outcome in patients with chronic low back pain. European Spine Journal, 24 (11), 2425–2431. DOI: 10.1007/s00586-015-3866-5. |
| 91. | Orlova, I.A., Alexander, G.M., Qureshi, R.A., Sacan, A., Graziano, A., Barrett, J.E., Schwartzman, R.J., Ajit, S.K. (2011). MicroRNA modulation in complex regional pain syndrome. Journal of Translational Medicine, 9 (1), 195. DOI: 10.1186/1479-5876-9-195. |
| 92. | Owens, B.D., Wolf, J.M., Seelig, A.D., Jacobson, I.G., Boyko, E.J., Smith, B., Ryan, M.A.K., Gackstetter, G.D., Smith, T.C. (2013). Risk factors for lower extremity tendinopathies in military personnel. Orthopaedic Journal of Sports Medicine, 1 (1), 1–8. DOI:10.1177/2325967113492707. |
| 93. | Packiasabapathy, S., Horn, N., Sadhasivam, S. (2019). HHS Public Access. 31 (6), 749–755. DOI: 10.1097/ACO.0000000000000660. Park, D.J., Kim, S.H., Nah, S.S., Lee, J.H., Kim, S.K., Lee, Y.A., Hong, S.J., Kim, H.S., Lee, H.S., Kim, H.A., Joung, C.I., Kim, S.H., Lee, S.S. (2016). Association between catechol-O-methyl transferase gene polymorphisms and fibromyalgia in a Korean population: A case-control study. European Journal of Pain (United Kingdom), 20 (7), 1131–1139. DOI: 10.1002/ejp.837. |
| 94. | Patanwala, I.Y., Lamvu, G., Ledger, W.J., Witzeman, K., Marvel, R., Rapkin, A., Bongiovanni, A.M., Feranec, J., Witkin, S.S. (2017). Catechol-O- methyltransferase gene polymorphism and vulvar pain in women with vulvodynia. American Journal of Obstetrics and Gynecology, 216 (4), 395.e1–395.e6. DOI: 10.1016/j.ajog.2016.10.020. |
| 95. | Peters, M.J., Broer, L., Willemen, H.L.D.M., Eiriksdottir, G., Hocking, L.J., Holliday, K.L., Horan, M.A., Meulenbelt, I., Neogi, T.,Popham, M., Schmidt, C.O., Soni, A., Valdes, A.M., Amin, N., Dennison, E.M., Eijkelkamp, N., Harris, T.B., Hart, D.J., Hofman, A., Huygen, F.J., Jameson, K.A., Jones, G.T., Laune, L.J., Kerkhof, H.J., de Kruijf, M., McBeth, J., Kloppenburg, M., Ollie, W.E., Oostra, B., Payton, A., Rivadeneira, F., Smith, B.H., Smith, A.V., Stolk, L., Teumer, A., Thomson, W., Uitterlinden, A.G., Wang, K., van Wingerden, S.H., Arden, N.K., Cooper, C., Felson, D., Gudnason, V., Macfarlane, G.J., Pendleton, N., Slagboom, P.E., Spector, T.D., Völzke, H., Kavelaars, A., van Duijn, C.M., Williams, F.M., Van Meurs, J.B.J. (2013). Genome-wide association study meta-analysis of chronic widespread pain: Evidence for involvement of the 5p15.2 region. Annals of the Rheumatic Diseases, 72 (3), 427–436. DOI: 10.1136/annrheumdis-2012-201742. |
| 96. | Planello, A.C., Campos, M.I.G., Meloto, C.B., Secolin, R., Rizatti-Barbosa, C.M., Line, S.R.P., De Souza, A.P. (2011). Association of matrix metalloproteinase gene polymorphism with temporomandibular joint degeneration. European Journal of Oral Sciences, 119 (1), 1–6. DOI: 10.1111/j.1600-0722.2010.00803.x. |
| 97. | Plinsinga, M.L., Brink, M.S., Vicenzino, B., van Wilgen, C.P. (2015). Evidenceof Nervous System Sensitization in Commonly Presenting and Persistent Painful Tendinopathies: A Systematic Review. Journal of Orthopaedic & Sports Physical Therapy, 45 (11), 864–875. DOI: 10.2519/jospt.2015.5895. |
| 98. | Rahim, M., Gibbon, A., Collins, M., September, A.V. (2019). Geneticsof musculoskeletal soft tissue injuries: Current status, challenges, and future directions. Sports, Exercise, and Nutritional Genomics: Current Status and Future Directions, 317–339. DOI: 10.1016/B978-0-12-816193-7.00015-4. |
| 99. | Raine, E.V.A., Dodd, A.W., Reynard, L.N., Loughlin, J. (2013). Allelic expression analysis of the osteoarthritis susceptibility gene COL11A1 in human joint tissues. BMC Musculoskeletal Disorders, 14 (1), 1.DOI: 10.1186/1471-2474-14-85. |
| 100. | Reimann, F., Cox, J.J., Belfer, I., Diatchenko, L., Zaykin, D.V, McHale, D.P., Drenth, J.P.H., Dai, F., Wheeler, J., Sanders, F., Wood, L., Wu, T.-X., Karppinen, J., Nikolajsen, L., Mannikko, M., Max, M.B., Kiselycznyk, C., Poddar, M., Te Morsche, R.H.M., ...,Woods, C.G. (2010). Pain perception is altered by a nucleotide polymorphism in SCN9A. Proceedings of the National Academy of Sciences of the United States of America, 107 (11), 5148–5153. DOI: 10.1073/pnas.0913181107. |
| 101. | Reyes-Gibby, C.C., Spitz, M.R., Yennurajalingam, S., Swartz, M., Jian, G., Xifeng, W., Bruera, E., Shete, S. (2009).Role of inflammation gene polymorphisms on pain severity in lung cancer patients. Cancer Epidemiology Biomarkers and Prevention, 18 (10), 2636–2642. DOI: 10.1158/1055-9965.EPI-09-0426. |
| 102. | Richardson, S.M., Doyle, P., Minogue, B.M., Gnanalingham, K., Hoyland, J.A. (2009). Increased expression of matrix metalloproteinase-10, nerve growth factor and substance P in the painful degenerate intervertebral disc. Arthritis Research and Therapy, 11 (4), 1–8.DOI: 10.1186/ar2793. |
| 103. | Rio, E., Moseley, L., Purdam, C., Samiric, T., Kidgell, D., Pearce, A.J., Jaberzadeh, S., Cook, J. (2014). The pain of tendinopathy: Physiological or pathophysiological? In Sports Medicine, 44 (1), 9–23. DOI: 10.1007/s40279-013-0096-z. |
| 104. | Roussos, P., Giakoumaki, S.G., Pavlakis, S., Bitsios, P. (2008). Planning, decision-making and the COMT rs4818 polymorphism in healthy males. Neuropsychologia, 46 (2), 757–763. DOI: 10.1016/j.neuropsychologia.2007.10.009. |
| 105. | Ruau, D., Dudley, J.T., Chen, R., Phillips, N.G., Swan, G.E., Lazzeroni, L.C., Clark, J.D., Butte, A.J., Angst, M.S. (2012). Integrative approach to pain genetics identifies pain sensitivity loci across diseases. PLoS Computational Biology, 8 (6). DOI: 10.1371/journal.pcbi.1002538. |
| 106. | Rydman, E., Comasco, E., Pettersson, H., Oreland, L., Ponzer, S., Ottosson, C. (2017). COMT genotype and non-recovery after awhiplash injury in a Northern European population. BMC Musculoskeletal Disorders, 18 (1), 4–10. DOI: 10.1186/s12891-017-1810-z. |
| 107. | Sadhasivam, S., Chidambaran, V., Olbrecht, V.A., Esslinger, H.R., Zhang, K., Zhang, X., Martin, L.J. (2014). Genetics of pain perception, COMT and postoperative pain management in children. Pharmacogenomics, 15 (3), 277–284. DOI: 10.2217/pgs.13.248. |
| 108. | Sanz-Rubio, D., Martin-Burriel, I., Gil, A., Cubero, P., Forner, M., Khalyfa, A., Marin, J.M. (2018). Stability of Circulating Exosomal miRNAs in Healthy Subjects article. Scientific Reports, 8 (1), 1–10. DOI: 10.1038/s41598-018-28748-5. |
| 109. | Saunders, C.J., Van Der Merwe, L., Posthumus, M., Cook, J., Handley, C.J., Collins, M., September, A.V. (2013). Investigationof variants within the COL27A1 and TNC genes and Achilles tendinopathy in two populations. Journal of Orthopaedic Research, 31 (4), 632–637. DOI:10.1002/jor.22278. |
| 110. | Schistad, E.I., Jacobsen, L.M., R0e, C., Gjerstad, J. (2014). The interleukin- 1a gene C > T polymorphism rs1800587 is associated with increased pain intensity and decreased pressure pain thresholds in patients with lumbar radicular pain. Clinical Journal of Pain, 30 (10), 869–874. DOI: 10.1097/AJP.0000000000000048. |
| 111. | Schizas, N., Weiss, R., Lian, O., Frihagen, F., Bahr, R., Ackermann, P.W. (2012). Glutamate receptors in tendinopathic patients.Journal of Orthopaedic Research, 30 (9), 1447–1452. DOI: 10.1002/jor.22094. |
| 112. | Seale, K., Burger, M., Posthumus, M., Hager, C.K., Stattin, E., Nilsson, K.G., Collins, M., September, A.V. (2020).The Apoptosis Pathway and CASP8 Variants Conferring Risk for Acute and Overuse Musculoskeletal Injuries. Journal of Orthopaedic Research, 38 (3), 680–688. DOI: 10.1002/jor.24504. |
| 113. | September, A.V., Nell, E.M., O’Connell, K., Cook, J., Handley, C.J., Van Der Merwe, L., Schwellnus, M., Collins, M. (2011). A pathway- based approach investigating the genes encoding interleukin-ip, interleukin-6 and the interleukin-1 receptor antagonist provides new insight into the genetic susceptibility of Achilles tendinopathy. British Journal of Sports Medicine, 45 (13), 1040–1047. DOI: 10.1136/bjsm.2010.076760. |
| 114. | September, A.V, Cook, J., Handley, C.J., van der Merwe, L., Schwellnus, M.P., Collins, M. (2009). Variants within the COL5A1 gene are associated with Achilles tendinopathy in two populations. British Journal of Sports Medicine, 43 (5), 357–365. DOI: 10.1136/bjsm.2008.048793. |
| 115. | Silbernagel, K.G., Hanlon, S., Sprague, A. (2020). Current clinical concepts: Conservative management of achilles tendinopathy. Journal of Athletic Training, 55 (5), 438–447. DOI: 10.4085/1062-6050-356-19. |
| 116. | Smolka, M.N., Schumann, G., Wrase, J., Grusser, S.M., Flor, H., Mann, K., Braus, D.F., Goldman, D., Buchel, C., Heinz, A. (2005). Catechol-O- methyltransferase val158met genotype affects processing of emotional stimuli in the amygdala and prefrontal cortex. Journal of Neuroscience, 25 (4), 836–842. DOI: 10.1523/JNEUROSCI.1792-04.2005. |
| 117. | Solovieva, S., Leino-Arjas, P., Saarela, J., Luoma, K., Raininko, R., Riihimaki, H. (2004). Possible associationof interleukin 1 gene locus polymorphisms with low back pain. Pain, 109 (1–2), 8–19. DOI: 10.1016/j.pain.2003.10.020. |
| 118. | Stephens, K., Cooper, B.A., West, C., Paul, S.M., Baggott, C.R., Merriman, J.D., Dhruva, A., Kober, K.M., Langford, D.J., Leutwyler, H., Luce, J A., Schmidt, B.L., Abrams, G.M., Elboim, C., Hamolsky, D., Levine, J.D., Miaskowski, C., Aouizerat, B.E. (2014). Associations between cytokine gene variations and severe persistent breast pain in women following breast cancer surgery. Journal of Pain, 15 (2), 169–180. DOI: 10.1016/j.jpain.2013.09.015. |
| 119. | Stephens, K.E., Levine, J.D., Aouizerat, B.E., Paul, S.M., Abrams, G., Conley, Y.P., Miaskowski, C. (2017). Associations between genetic and epigenetic variations in cytokine genes and mild persistent breast pain in women following breast cancer surgery. Cytokine, 99, 203–213. DOI: 10.1016/j.cyto.2017.07.006 |
| 120. | Suijkerbuijk, M.A.M., Ponzetti, M., Rahim, M., Posthumus, M. (2020). Functional polymorphisms within the inflammatory pathway regulate expression of extracellular matrix components in a genetic risk dependent model for anterior cruciate ligament injuries. Journal of Science and Medicine in Sport, 22 (11), 1219–1225. DOI: 10.1016/j.jsams.2019.07.012. |
| 121. | Takigawa, H., Kowa, H., Nakashima, K. (2017). No associations between five polymorphisms in COMT gene and migraine. Acta Neurologica Scandinavica, 135 (2), 225–230. DOI: 10.1111/ane.12583. |
| 122. | Tammimaki, A., Mannisto, P.T. (2012). Catechol-O-methyltransferase gene polymorphism and chronic human pain: A systematic review and meta- analysis. Pharmacogenetics and Genomics, 22 (9), 673–691. DOI: 10.1097/FPC.0b013e3283560c46. |
| 123. | Tchivileva, I.E., Lim, P.F., Smith, S.B., Slade, G.D., Diatchenko, L., Mclean, S. a, Maixner, W. (2011). Effectof catechol-O-methyltransferase polymorphism on response to propranolol therapy in chronic musculoskeletal pain: a randomized, double-blind, placebo-controlled, crossover pilot study. Pharmacogenet Genomics, 20 (4), 239–248. DOI: 10.1097/FPC.0b013e328337f9ab. |
| 124. | Tompra, N., Van Dieen, J.H., Coppieters, M.W. (2016). Central pain processing is altered in people with Achilles tendinopathy. British Journal of Sports Medicine, 50 (16), 1004–1007. DOI: 10.1136/bjsports-2015-095476. |
| 125. | Toyama, K., Kiyosawa, N., Watanabe, K., Ishizuka, H. (2017). Identification of circulating miRNAs differentially regulated by opioid treatment. International Journal of Molecular Sciences, 18 (9). DOI: 10.3390/ijms18091991. |
| 126. | Van Ark, M., Rio, E., Cook, J., Van Den Akker-Scheek, I., Gaida, J.E., Zwerver, J., Docking, S. (2018). Clinical improvements are not explained by changes in tendon structure on ultrasound tissue characterization after an exercise program for patellar tendinopathy. American Journal of Physical Medicine and Rehabilitation, 97 (10), 708–714. DOI: 10.1097/PHM.0000000000000951. |
| 127. | van Esch, A.A.J., de Vries, E., te Morsche, R.H.M., van Oijen, M.G.H., Jansen, J. B.M.J., Drenth, J.P.H. (2011). Catechol-O- methyltransferase (COMT) gene variants and pain in chronic pancreatitis. Netherlands Journal of Medicine, 69 (7), 330–334. |
| 128. | Veluchamy, A., Hebert, H.L., Meng, W., Palmer, C.N.A., Smith, B.H. (2018). Systematic review and meta-analysisof genetic risk factors for neuropathic pain. Pain, 159 (5), 825–848. DOI: 10.1097/j.pain.0000000000001164. |
| 129. | Vick, J.S.,Askwith, C.C. (2015). ASICs and neuropeptides.Neuropharmacology, 94, 36–41. DOI: 10.1016/j.neuropharm.2014.12.012. |
| 130. | Vuoristo, M.M., Pappas, J.G., Jansen, V., Ala-Kokko, L. (2004). A stop codon mutation in COL11A2 induces exon skipping and leads to non-ocular stickler syndrome. American Journal of Medical Genetics, 130 A(2), 160–164. DOI: 10.1002/ajmg.a.30111. |
| 131. | Wang, L., Wei, C., Xiao, F., Chang, X., Zhang, Y. (2019). Influencesof COMT rs4680 and OPRM1 rs1799971 Polymorphisms on Chronic Postsurgical Pain, Acute Pain, and Analgesic Consumption after Elective Cesarean Delivery. Clinical Journal of Pain, 35 (1),31–36. DOI: 10.1097/AJP.0000000000000654. |
| 132. | Waxman, S.G., Merkies, I.S.J., Gerrits, M.M., Dib-Hajj, S.D., Lauria, G., Cox, J.J., Wood, J.N., Woods, C.G., Drenth, J.P.H., Faber, C.G. (2014). Sodium channel genes in pain-related disorders: phenotype-genotype associations and recommendations for clinical use. The Lancet Neurology, 13 (11), 1152–1160. DOI: 10.1016/S1474-4422(14)70150-4. |
| 133. | Zhang, X.Y., Wen, J., Yang, W., Wang, C., Gao, L., Zheng, L.H., Wang, T., Ran, K., Li, Y., Li, X., Xu, M., Luo, J., Feng, S., Ma, X., Ma, H., Chai, Z., Zhou, Z., Yao, J., Zhang, X., Liu, J.Y. (2013). Gain-of-Function mutations in SCN11A cause familial episodic pain. American Journal of Human Genetics, 93 (5), 957–966. DOI: 10.1016/j.ajhg.2013.09.016. |
| 134. | Zhou, L.L., Zhu, Y.M., Qian, F.Y., Yuan, C.C., Yuan, D.P., Zhou, X.P. (2018). MicroRNA-143-3p contributes to the regulation of pain responses in collagen-induced arthritis. Molecular Medicine Reports, 18 (3), 3219–3228. DOI: 10.3892/mmr.2018.9322. |