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Central European Journal of Sport Sciences and Medicine
Vol. 50, No. 2/2025
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Effect of exercise on GABA: A systematic review of the literature

DOI: 10.18276/cej.2025.2-04
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ISSN:2300-9705
eISSN:2353-2807
Autorzy: Dilip Roy ORCID
Department of Physical Education, Jadavpur University, Kolkata-700032, West Bengal, India

Prosanta Paul ORCID
Department of Physical Education, Jadavpur University, Kolkata-700032, West Bengal, India

Puneet Bhattacharya ORCID
Department of Physical Education, Jadavpur University, Kolkata-700032, West Bengal, India

Sridip Chatterjee ORCID
Department of Physical Education, Jadavpur University, Kolkata-700032, West Bengal, India
Słowa kluczowe: GABA neurotransmitter physical exercise cognitive health psychology
Data publikacji całości:2025
Liczba stron:11 (41-51)
OAI-PMH:Metadane
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Abstrakt

Physical exercise (PE) has improved brain function by encouraging neuroplasticity via a number of different neurobiological processes. Gama-amino butyric acid (GABA) has potentiality to modify neuroplastic capacity of neurons through trophic action. L-glutamata of the brain naturally produces GABA while focused scientific analysis is now towards its physiological influence towards brain health. Investigation shows very less research between these two factors, and no comprehensive review study so far. The present study based on PRISMA-P, 2015 guidelines accumulated latest information to better understand how physical exercise influences GABA levels in the brain. Using the PRISMA 2020 flow diagram, a rational approach was guaranteed during the screening process for existing literature that meets the criteria. These existing non-randomized controlled trials (Non-RCT) and randomized controlled trials (RCT) have shown that aerobic interventions boost GABA levels in the human brain that has a positive impact. This innate benefit may be considered as a form of medicinal and remedial treatment for depression, anxiety disorders, and in general cognitive health. These results, which are associated with increased GABA exposure and its mechanism, imply that exercise has the potential to be an intervention for enhancing psychological competence or cognitive health, executive function, and sport performance as well.

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Bibliografia (49)
  1. Ball, J. (2022b). Special section: Relationships between Executive Function and Sports / Exercise. Perceptual and Motor Skills, 129(4), 969–976. https://doi.org/10.1177/00315125221108550
  2. Barha, C. K., Galea, L. A., Nagamatsu, L. S., Erickson, K. I., & Liu-Ambrose, T. (2016). Personalising exercise recommendations for brain health: considerations and future directions. British Journal of Sports Medicine, 51(8), 636–639. https://doi.org/10.1136/bjsports-2016-096710
  3. Barnes, D. E., Yaffe, K., Satariano, W. A., & Tager, I. B. (2003). A longitudinal study of cardiorespiratory fitness and cognitive function in healthy older adults. Journal of the American Geriatrics Society, 51(4), 459–465. https://doi.org/10.1046/j.1532-5415.2003.51153.x
  4. Bowery, N. G., & Smart, T. G. (2006). GABA and glycine as neurotransmitters: a brief history. British Journal of Pharmacology, 147(S1). https://doi.org/10.1038/sj.bjp.0706443
  5. Braga, J. D., Thongngam, M., & Kumrungsee, T. (2024). Gamma-aminobutyric acid as a potential postbiotic mediator in the gut–brain axis. npj Science of Food, 8(1), 16.
  6. Caspersen, C. J., Powell, K. E., & Christenson, G. M. (1985). Physical activity, exercise, and physical fitness: definitions and distinctions for health-related research. PubMed, 100(2), 126–131. https://pubmed.ncbi.nlm.nih.gov/3920711
  7. Chiodera, P., Gnudi, A., Volpi, R., Marchesi, C., Marchesi, M., Davoli, D., Capretti, L., & Coiro, V. (1989b). Effects of the gabaergic agent sodium valproate on the arginine vasopressin responses to hypertonic stimulation and upright posture in man. Clinical Endocrinology, 30(4), 389–395. https://doi.org/10.1111/j.1365-2265.1989.tb00437.x
  8. Côté, J., Macdonald, D. J., Baker, J., & Abernethy, B. (2006). When “where” is more important than “when”: Birthplace and birthdate effects on the achievement of sporting expertise. Journal of Sports Sciences, 24(10), 1065–1073. https://doi.org/10.1080/02640410500432490
  9. Cotman, C., & Berchtold, N. C. (2002). Exercise: a behavioral intervention to enhance brain health and plasticity. Trends in Neurosciences, 25(6), 295–301. https://doi.org/10.1016/s0166-2236(02)02143-4
  10. Coxon, J. P., Cash, R. F. H., Hendrikse, J. J., Rogasch, N. C., Stavrinos, E., Suo, C., & Yücel, M. (2017). GABA concentration in sensorimotor cortex following high‐intensity exercise and relationship to lactate levels. Journal of Physiology, 596(4), 691–702. https://doi.org/10.1113/jp274660
  11. Diamond, A. (2013). Executive functions. Annual Review of Psychology, 64(1), 135–168. https://doi.org/10.1146/annurev-psych-113011-143750
  12. Fisher, G. G., Chacon, M., & Chaffee, D. S. (2019). Theories of cognitive aging and work. In Elsevier eBooks (pp. 17–45). https://doi.org/10.1016/b978-0-12-812756-8.00002-5
  13. Fu, Y., Tucciarone, J. M., Espinosa, J. S., Sheng, N., Darcy, D. P., Nicoll, R. A., Huang, Z. J., & Stryker, M. P. (2014). A cortical circuit for gain control by behavioral state. Cell, 156(6), 1139–1152. https://doi.org/10.1016/j.cell.2014.01.050
  14. Guiney, H., & Machado, L. (2012). Benefits of regular aerobic exercise for executive functioning in healthy populations. Psychonomic Bulletin & Review, 20(1), 73–86. https://doi.org/10.3758/s13423-012-0345-4
  15. Heyn, P., Abreu, B. C., & Ottenbacher, K. J. (2004). The effects of exercise training on elderly persons with cognitive impairment and dementia: A meta-analysis11No commercial party having a direct financial interest in the results of the research supporting this article has or will confer a benefit upon the author(s) or upon any organization with which the author(s) is/are associated. Archives of Physical Medicine and Rehabilitation, 85(10), 1694–1704. https://doi.org/10.1016/j.apmr.2004.03.019
  16. Hillman, C. H., Belopolsky, A. V., Snook, E. M., Kramer, A. F., & McAuley, E. (2004). Physical Activity and Executive Control: Implications for Increased Cognitive Health during Older Adulthood. Research Quarterly for Exercise and Sport, 75(2), 176–185. https://doi.org/10.1080/02701367.2004.10609149
  17. Huijgen, B., Elferink-Gemser, M., Ali, A., & Visscher, C. (2013). Soccer skill development in talented players. International Journal of Sports Medicine, 34(08), 720–726. https://doi.org/10.1055/s-0032-1323781
  18. Huijgen, B. C. H., Leemhuis, S., Kok, N. M., Verburgh, L., Oosterlaan, J., Elferink-Gemser, M. T., & Visscher, C. (2015). Cognitive functions in elite and Sub-Elite youth soccer players aged 13 to 17 years. PloS One, 10(12), e0144580. https://doi.org/10.1371/journal.pone.0144580
  19. Klintsova, A. Y., Dickson, E., Yoshida, R., & Greenough, W. T. (2004). Altered expression of BDNF and its high-affinity receptor TrkB in response to complex motor learning and moderate exercise. Brain Research, 1028(1), 92–104. https://doi.org/10.1016/j.brainres.2004.09.003
  20. Larson, E. B., Wang, L., Bowen, J. D., McCormick, W. C., Teri, L., Crane, P., & Kukull, W. (2006). Exercise Is Associated with Reduced Risk for Incident Dementia among Persons 65 Years of Age and Older. Annals of Internal Medicine, 144(2), 73. https://doi.org/10.7326/0003-4819-144-2-200601170-00004
  21. Jonasson, L. S., Nyberg, L., Kramer, A. F., Lundquist, A., Riklund, K., & Boraxbekk, C. J. (2017). Aerobic exercise intervention, cognitive performance, and brain structure: results from the physical influences on brain in aging (PHIBRA) study. Frontiers in aging neuroscience, 8, 336.
  22. Lozano Montes, L., Balakrishnan, V., & Gopalakrishnan, S. (2021). Effects of integrated amrita meditation technique on anxiety, depression, and plasma neurotransmitters on a healthy population: a randomized controlled trial followed by a case–control study. The Journal of Alternative and Complementary Medicine, 27(8), 641-648.
  23. Lautenschlager, N. T., & Almeida, O. P. (2006). Physical activity and cognition in old age. Current Opinion in Psychiatry, 19(2), 190–193. https://doi.org/10.1097/01.yco.0000214347.38787.37
  24. Maddock, R. J., Casazza, G. A., Fernandez, D. H., & Maddock, M. I. (2016). Acute modulation of cortical glutamate and GABA content by physical activity. ˜the œJournal of Neuroscience/˜the œJournal of Neuroscience, 36(8), 2449–2457. https://doi.org/10.1523/jneurosci.3455-15.2016
  25. Masley, S., Roetzheim, R., & Gualtieri, T. (2009). Aerobic exercise enhances cognitive flexibility. Journal of Clinical Psychology in Medical Settings, 16(2), 186–193. https://doi.org/10.1007/s10880-009-9159-6
  26. Mesquita, I. (1998). The multidimensionality in the domain of the volleyball skills. In IV World Congress of Natational Analysis of Sport. Porto, Portugal: Multitema (pp. 147-55).
  27. Moher, D., Shamseer, L., Clarke, M., Ghersi, D., Liberati, A., Petticrew, M., Shekelle, P., & Stewart, L. A. (2015). Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Systematic Reviews, 4(1). https://doi.org/10.1186/2046-4053-4-1
  28. Mooney, R. A., Coxon, J. P., Cirillo, J., Glenny, H., Gant, N., & Byblow, W. D. (2016). Acute aerobic exercise modulates primary motor cortex inhibition. Experimental Brain Research, 234(12), 3669–3676. https://doi.org/10.1007/s00221-016-4767-5
  29. Mummery, K., Schofield, G., & Caperchione, C. (2004). Physical activity: Physical activity dose‐response effects on mental health status in older adults. Australian and New Zealand Journal of Public Health, 28(2), 188–192. https://doi.org/10.1111/j.1467-842x.2004.tb00934.x
  30. Novak, T. S., McGregor, K. M., Krishnamurthy, L. C., Evancho, A., Mammino, K., Walters Jr, C. E., ... & Nocera, J. R. (2024). GABA, aging and exercise: functional and intervention considerations. Neuroscience Insights, 19, 26331055241285880.
  31. Pahlavani, H. A. (2024). Possible role of exercise therapy on depression: Effector neurotransmitters as key players. Behavioural Brain Research, 459, 114791. https://doi.org/10.1016/j.bbr.2023.114791
  32. Paul, P., Roy, D., Bhattacharya, P., & Chatterjee, S. (2024). Team Sports and Executive Functions: A comparative observational pilot study. UndongGwahag, 33(1), 77–83. https://doi.org/10.15857/ksep.2023.00353
  33. Perucca, E., Bialer, M., & White, H. S. (2023). New GABA-targeting therapies for the treatment of seizures and epilepsy: I. Role of GABA as a modulator of seizure activity and recently approved medications acting on the GABA system. CNS drugs, 37(9), 755-779
  34. Pierrefiche, O., Foutz, A. S., & Denavit-Saubié, M. (1993). Effects of GABAB receptor agonists and antagonists on the bulbar respiratory network in cat. Brain Research, 605(1), 77–84. https://doi.org/10.1016/0006-8993(93)91358-y
  35. Raichlen, D. A., & Polk, J. D. (2013). Linking brains and brawn: exercise and the evolution of human neurobiology. Proceedings - Royal Society. Biological Sciences/Proceedings - Royal Society. Biological Sciences, 280(1750), 20122250. https://doi.org/10.1098/rspb.2012.2250
  36. Roth, D. L., Goode, K. T., Clay, O. J., & Ball, K. K. (2003). Association of physical activity and visual attention in older adults. Journal of Aging and Health, 15(3), 534–547. https://doi.org/10.1177/0898264303253512
  37. Shi, Y., & Qu, S. (2021). Cognitive Ability and Self-Control’s influence on high school students’ comprehensive academic performance. Frontiers in Psychology, 12. https://doi.org/10.3389/fpsyg.2021.783673
  38. Sideraki, A., & Drigas, A. (2024). GABA and Executive Functions in ASD. Scientific Electronic Archives, 17(3).
  39. Singh-Manoux, A., Hillsdon, M., Brunner, E., & Marmot, M. (2005). Effects of physical activity on cognitive functioning in Middle Age: Evidence from the Whitehall II Prospective Cohort Study. American Journal of Public Health, 95(12), 2252–2258. https://doi.org/10.2105/ajph.2004.055574
  40. Streeter, C. C., Jensen, J. E., Perlmutter, R. M., Cabral, H. J., Tian, H., Terhune, D. B., Ciraulo, D. A., & Renshaw, P. F. (2007). Yoga Asana sessions increase brain GABA levels: a pilot study. ˜the œJournal of Alternative and Complementary Medicine/Journal of Alternative and Complementary Medicine, 13(4), 419–426. https://doi.org/10.1089/acm.2007.6338
  41. Streeter, C. C., Whitfield, T. H., Owen, L., Rein, T., Karri, S. K., Yakhkind, A., Perlmutter, R., Prescot, A., Renshaw, P. F., Ciraulo, D. A., & Jensen, J. E. (2010). Effects of yoga versus walking on mood, anxiety, and brain GABA levels: a randomized controlled MRS study. ˜the œJournal of Alternative and Complementary Medicine/Journal of Alternative and Complementary Medicine, 16(11), 1145–1152. https://doi.org/10.1089/acm.2010.0007
  42. Streeter, C. C., Gerbarg, P. L., Nielsen, G. H., Brown, R. P., Jensen, J. E., & Silveri, M. M. (2018). Effects of yoga on thalamic gamma-aminobutyric acid, mood and depression: Analysis of two randomized controlled trials. Neuropsychiatry (London), 8(6), 1923.
  43. Swain, R., Harris, A., Wiener, E., Dutka, M., Morris, H., Theien, B., Konda, S., Engberg, K., Lauterbur, P., & Greenough, W. (2003). Prolonged exercise induces angiogenesis and increases cerebral blood volume in primary motor cortex of the rat. Neuroscience, 117(4), 1037–1046. https://doi.org/10.1016/s0306-4522(02)00664-4
  44. Tınok, A. A., Karabay, A., Jong, J. D., Balta, G., & Akyürek, E. G. (2023). Effects of gamma-aminobutyric acid on working memory and attention: A randomized, double-blinded, placebo-controlled, crossover trial. Journal of Psychopharmacology, 37(6), 554-565.)
  45. Verburgh, L., Scherder, E. J. A., Van Lange, P. A., & Oosterlaan, J. (2014). Executive functioning in highly talented soccer players. PloS One, 9(3), e91254. https://doi.org/10.1371/journal.pone.0091254
  46. Vestberg, T., Reinebo, G., Maurex, L., Ingvar, M., & Petrovic, P. (2017). Core executive functions are associated with success in young elite soccer players. PloS One, 12(2), e0170845. https://doi.org/10.1371/journal.pone.0170845
  47. Weuve, J. (2004). Physical activity, including walking, and cognitive function in older women. JAMA, 292(12), 1454. https://doi.org/10.1001/jama.292.12.1454
  48. Xiong, J., Ma, L., Wang, B., Narayana, S., Duff, E. P., Egan, G. F., & Fox, P. T. (2009). Long-term motor training induced changes in regional cerebral blood flow in both task and resting states. NeuroImage, 45(1), 75–82. https://doi.org/10.1016/j.neuroimage.2008.11.016
  49. Zeng, N., Ayyub, M., Sun, H., Wen, X., Xiang, P., & Gao, Z. (2017). Effects of physical activity on motor skills and cognitive development in early Childhood: a systematic review. BioMed Research International, 2017, 1–13. https://doi.org/10.1155/2017/2760716